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Publications

Papers: 

 

2015 - date

 

Kehl, K., A. Schallenberg, C. Szekat, C. Albert, E. Sib, M. Exner, N. Zacharias, C. Schreiber, M. Parcina, G. Bierbaum. 2022. Dissemination of carbapenem resistant bacteria from hospital wastewater into the environment. Sci Total Environ. 806(Pt 4):151339.

Hort, M. U. Bertsche, S. Nozinovic, A. Dietrich, S.S. Schrötter, L. Mildenberger, K. Axtmann, A. Berscheid, G. Bierbaum. 2021. The Role of ß-Glycosylated wall teichoic acids in teh reduction of Vancomycin susceptibility in Vancomycin-inermediate Stapylococcus aureus. Microbiol Spectr 9(2):e0052821

Janssen, K. S.L. Low, Y. Wang, Q.Y. Mu, G. Bierbaum, C.T. Gee. 2021.Elucidating biofilm diversity on water lily leaves through 16S rRNA amplicon analysis: Comparison of four DNA extraction kits. Appl Plant Sci. 9(8):e11444

Janssen, K. B. Mähler, J. Rust, G. Bierbaum, V.E. McCoy. 2021. The compolex role of microbial metabolic activity in fossilization. Biol Rev Camb Philos Soc. doi: 10.1111/brv.12806. Online ahead of print.

Savin, M., J. Alexander, G. Bierbaum, J.A. Hammerl, N. Hembach, T. Schwartz, R.M. Schmithausen, E. Sib, A. Voigt, J. Kreyenschmidt. 2021. Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatment. Sci Rep. 11(1):16622

Schreiber, C., N. Zacharias, S.M Essert, F. Wasser, H. Müller, E. Sib, T. Precht, M. Parcina, G. Bierbaum, R.M. Schmithausen, T. Kistemann, M. Exner. 2021. Clinically relevant antibiotic-resistant bacteria in aquatic environments - An optimized culture-based approach. Sci Total Environ. 750:142265. doi: 10.1016/j.scitotenv.2020.142265.

Singer, L., K. Kehl, G. Bierbaum, C.P. Bourauel. 2020. Evaluation of the flexural strength, water sorption and solubility of a dental cement modified using phytomedicine. Materials.13(23):5352. doi: 10.3390/ma13235352.

Mähler, B., K. Janssen, M. Mennecken, M. Tahoun, M. Lagos, G. Bierbaum, C. Müller, J. Rust. 2020. Calcite precipitation forms crystal clusters and muscle mineralization during the decomposition of Cambarellus diminutus (Decapoda: Cambaridae) in freshwater. Paleontologia electronica. 23(3):a55. https://doi.org/10.26879/992.

Singer, L., G. Bierbaum, K. Kehl, C. Bourauel. 2020. Evaluation of the antimicrobial activity and compressive strength of a dental cement modified using plant extract mixture. Journal of Materials Science: Materials in Medicine. 31(12):116. doi: 10.1007/s10856-020-06455-w.

Savin, M., G. Bierbaum, K. Blau, M. Parcina, E. Sib, K. Smalla, R. Schmithausen, C. Heinemann, J. A. Hammerl, J. Kreyenschmidt . 2020. Colistin-Resistant Enterobacteriaceae isolated from process waters and wastewater from German poultry and pig slaughterhouses. Front Microbiol. 11:575391

Peris, D., K. Janssen, H. J. Barthel, G. Bierbaum, X. Delclòs, E. Peñalver, M. M. Solórzano-Kraemer, B. H. Jordal, J. Rust. 2020. DNA from resin-embedded organisms: Past, present and future. PLoS One. 15(9):e0239521

Sib, E., F. Lenz-Plet, V. Barabasch, U. Klanke, M. Savin, N. Hembach, A. Schallenberg, K. Kehl , C. Albert, M. Gajdiss, N. Zacharias, H. Müller, R. M. Schmithausen, M. Exner, J. Kreyenschmidt , C. Schreiber, T. Schwartz, M. Parčina, G. Bierbaum. 2020. Bacteria isolated from hospital, municipal and slaughterhouse wastewaters show characteristic, different resistance profiles. Sci Total Environ. 746:140894

Schreiber, C., N. Zacharias, S. M. Essert, F. Wasser , H. Müller, E. Sib, T. Precht, M. Parcina, G. Bierbaum, R. M. Schmithausen, T. Kistemann, M. Exner. 2020. Clinically relevant antibiotic-resistant bacteria in aquatic environments - An optimized culture-based approach. Sci Total Environ 750:142265

Gajdiss, M., I.R. Monk, U. Bertsche, J. Kienemund, T. Funk, A. Dietrich, M. Hort, E. Sib, T.P. Stinear, G. Bierbaum. 2020. YycH and Yycl regulate expression of Staphylococcus aureus autolysins by activation of WalRK phosphorylation. Microorganisms. 8(6):E870

Gäb, F., C. Ballhaus, E. Stinnesbeck, A.G. Kral, K. Janssen, G. Bierbaum. 2020. Experimental taphonomy of fish - role of elevated pressure, salinity and pH. Sci Rep. 10(1):7839

Savin, M., G. Bierbaum, J.A. Hammerl, C. Heinemann, M. Parcina, E. Sib, A. Voigt, J. Kreyenschmidt. 2020. Antibiotic-resistant bacteria and antimicrobial residues in wastewater and process water from German pig slaughterhaouses and their receiving municipal wastewater treatment plants. J Sci Total Environ. 727:138788

Savin, M., G. Bierbaum, J.A. Hammerl, C. Heinemann, M. Parcina, E. Sib, A. Voigt, J. Kreyenschmidt. 2020. ESKAPE Bacteria and extended-spectrum-ß-lactamase-producing Escherichia coli isolated from wastewater and process water from German poultry slaughterhouses. J Appl Environ Microbiol. 86(8):e02748-19

Schmithausen, R.M. E. Sib, M. Exner, S. Hack, C. Rösing, P. Ciorba, G. Bierbaum, M. Savin, S.F. Bloomfield, M. Kaase, A. Jacobshagen, S. Gemin, J. Gebel, S. Engelhart, D. Exner. 2019. The washing machine as a reservoir for transmission of extendet-spectrum-beta-lactamase (CTX-M-15)-producing Klebsiella oxytoca ST201 to newborns. Appl Environ Microbiol. 85(22):e01435

Voigt, A.M., N. Zacharias, C. Timm, F. Wasser, E. Sib, D. Skutlarek, M. Parcina, R.M. Schmithausen, T. Schwartz, N. Hembach, A. Tiehm, C. Stange, S. Engelhart, G. Bierbaum, T. Kistemann, M. Exner, H.A. Färber, C. Schreiber. 2019. Association between antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in anthropogenic wastewater - an evaluation of clinical influences. Chemosphere. 241:125032

Monk, I.R., N. Shaikh, S.L. Begg, M. Gajdiss, L.K.R. Sharkey, J.Y.H. Lee, S.J. Pidot, T. Seemann, M. Kuiper, B. Winnen, R. Hvorup, B.M. Collins, G. Bierbaum, S.R. Udagedara, J.R. Morey, N. Pulyani, B.P. Howden, M.J. Maher, C.A. McDevitt, G.F. King, T.P. Stinear. 2019. Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nat Commun. 10(1):3067

Sib, E., A.M. Voigt, G. Wilbring, C. Schreiber, H.A. Faerber, D. Skutlarek, M. Parcina, R. Mahn, D. Wolf, P. Brossart, F. Geiser, S. Engelhart, M. Exner, G. Bierbaum, R.M. Schmithausen. 2019. Antibiotic resistant bacteria and resistance genes in biofilm in clinical wastewater networks. Int J Hyg Environ Health. 222(4):655-662

Schuster, D., M. Josten, K. Janssen, I. Bodenstein, C. Albert, A. Schallenberg, M. Gajdiss, E. Sib, C. Szekat, K. Kehl, M. Parcina, G.T.R. Hischebeth, G. Bierbaum. 2018. Detection of methicillin-resistant coagulase-negative staphylococci harboring the class A mec complex by MALDI-TOF mass spectrometry. Int J Med Microbiol. 308(5):522-526

Müller, H., E. Sib, M. Gajdiss, U. Klanke, F. Lenz-Plet, V. Barabasch, C. Albert, A. Schallenberg, C. Timm, N. Zacharias, R.M. Schmithausen, S. Engelhart, M. Exner, M. Parcina, C. Schreiber, G. Bierbaum. 2018. Dissemination of multi-resistant Gram-negative bacteria into German wastewater and surface waters. FEMS Microbiology Ecology. 94(5) fiy057

Froeschen, F., M. Gajdiss, J. Uebele, A. Meilaender, A. Hoerauf, M. Exner, E. Molitor, G. Bierbaum, S. Engelhart, I. Bekeredjian-Ding. 2017. Rapid monitoring of local epidemiology of vancomycin-resistant Enterococcus faecium on a department level by repPCR. J Hosp Infect. 99(2):208-217

Eibach, D., M. Nagel, B. Hogan, C. Azuure, R. Krumkamp, D. Dekker, M. Gajdiss, M. Brunke, N. Sarpong, E. Owusu-Dabo. 2017. Nasal Carriage of Staphylococcus aureus among children in the Ashanti region of Ghana. PLoS One. 12(1):e0170320

Kleinert, F., R. Kallies, M. Hort, A. Zweynert, C. Szekat, M. Nagel, G. Bierbaum. 2017. Influence of IS256 on genome variablility and formation of SCV in Staphylococcus aureus. Antimicrob Agents Chemother. 61(8).pII:e00144-17

Uebele, J., C. Stein, M.T. Nguyen, A. Schneider, F. Kleinert, O. Tichá, G. Bierbaum, F. Götz, I. Bekeredjian-Ding. 2017. Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylocuccus aureus. PLoS Pathog. 13(5):e1006387

Schüller, A., D. Matzner, C.E. Lünse, V. Wittmann, C. Schumacher, S. Unsleber, H. Brötz-Österhelt, C. Mayer, G. Bierbaum, G. Mayer. 2017. Activation of the glmS ribozyme confers bacterial growth inhibition. Chembiochem. 18(5):435-440

Hardt, P., I. Engels, M. Rausch, M. Gajdiss, H. Ulm, P. Sass, K. Ohlsen, H.-G. Sahl, G. Bierbaum, T. Schneider, F. Grein. 2017. The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus. Int J Med Microbiol. 307(1):1-10
 

Gajdiss, M., M. Türck, G. Bierbaum. 2017. Bacterial histidine kinases: overexpression, purification, and inhibitor screen. Methods Mol Biol. 1520:247-259

Schuster, D., J. Rickmeyer, M. Gajdiss, T. Thye, S. Lorenzen, M. Reif, M. Josten, C. Szekat, L.D.R. Melo, R.M. Schmithausen, Fl. Liégeois, H.-G. Sahl, J.-P. J. Gonzalez, M. Nagel, G. Bierbaum. 2016. Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape. Int J Med Microbiol. 307(1):57-63

Kleinert, F., R. Kallies, A. Zweynert, G. Bierbaum. 2016. Draft genome sequences of three northern german epidemic Stapylococcus aureus (ST247) strains containing multiple copies of IS 256. Genome Announc 4(5):e00936-16

Grass, G., G. Bierbaum, E. Molitor, N. Götte, M. Antwerpen. 2016. Genome sequence of Bacillus pumilus strain Bonn, isolated from an antrax-like necrotic skin infection site of a child. Genome Announc 4(1):e01741-15

Schmithausen, R.M., S.V. Schulze-Geisthoevel, A. Hoerauf, M. Exner, G. Bierbaum, I. Bekeredjian-Ding, B. Petersen. 2016. MRSA und ESBL in pig production. Züchtungskunde 88 (1):52-65

Schäberle, T.F., A. Schmitz, G. Zocher, A. Schiefer, S. Kehraus, E. Neu, M. Roth, D.G. Vassylyev, T. Stehle, G. Bierbaum, A. Hoerauf, K. Pfarr, G.M. König.
2015. Insights into structure-activity relationships of bacterial RNA polymerase inhibiting corallopyronin derivatives. J Nat Prod. 78(10):2505-9

Schmithausen R.M.,  S.V. Schulze-Geisthoevel, F. Stemmer, M. El-Jade, M. Reif, S. Hack, A. Meilaender, G. Montabauer, R. Fimmers, M. Parcina, A. Hoerauf, M. Exner, B. Petersen, G. Bierbaum, I. Bekeredjian-Ding.
2015. Analysis of transmission of MRSA and ESBL-E among pigs and farm personnel. PlosOne 10(9):e0138173

Schmithausen, R.M., S.R. Kellner, S.V. Schulze-Geisthoevel, S. Hack, S. Engelhart, I. Bodenstein, N. Al-Sabti, M. Reif, R. Fimmers,B.  Körber-Irrgang, J. Harlizius, A. Hoerauf, M. Exner, G. Bierbaum, B. Petersen, I. Bekeredjian-Ding.
2015. Eradication of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae expressing extended-spectrum ß-lactamases (ESBL-E) on a model pig farm. Appl Environ Microbiol. 81(21):7633-43

Basi-Chipalu, S., J. Dischinger, M. Josten, C. Szekat, A. Zweynert, H.-G. Sahl, G. Bierbaum.
2015. Pseudomycoicidin, a class II lantibiotic from Bacillus. Appl Environ Microbiol. 81(10):3419-29

 

 

2010 - 2014

 

Wilmes M., M. Stockem, G. Bierbaum, M. Schlag, F. Götz, D.Q. Tran, J.B. Schaal, A.J. Ouellette, M.E. Selsted, H.-G. Sahl. 2014. Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel). 3(4):617-631.

Mazur, N., M. Nagel, U. Leppin, G. Bierbaum, J. Rust. 2014. The extraction of fossil arthropods from lower eocene cambay amber. Acta Palaeontologica Polonica.  59(2):455-459.

Münch, D., I. Engels, A. Müller, K. Reder-Christ, H. Falkenstein-Paul, G. Bierbaum, F. Grein, G. Bendas, H.-G. Sahl, T. Schneider. 2014. Structural variations of the cell wall precursor lipid II - Influence on binding and activity of the lipoglycopeptide antibiotic oritavancin. J Antimicrob Chemother. 59(2):772-781.

Berscheid, A., P.  François, A. Strittmatter, G. Gottschalk, J. Schrenzel, P. Sass, G. Bierbaum. 2014. Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS. J Antimicrob Chemother. 69(12):3190-98.

Josten, M., J. Dischinger, C. Szekat, M. Reif, N. Al-Sabti, H.-G. Sahl, M. Parcina, I. Bekeredjian-Ding, G. Bierbaum. 2014. Identification of agr-positive methicillin-resistant Staphylococcus aureus harbouring the class A mec complex by MALDI-TOF mass spectrometry. Int J Med Microbiol. 304:1018-1023.

Hilmi, D., M. Parcina, D. Stollewerk, J. Ostrop, M. Josten, A. Meilaender, U. Zaehringer, T.A. Wichelhaus, G. Bierbaum, K. Heeg, C. Wolz, I. Bekeredjian-Ding. 2014. Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates. PLoS One. 9(5):e96416.

Dischinger, J., S. Basi Chipalu, G. Bierbaum. 2014. Lantibiotics: promising candidates for future applications in health care. Int J Med Microbiol. 304(1):51-62.

Bierbaum, G., H.-G. Sahl. 2014. The search for new anti-infective drugs: untapped resources and strategies. Int J Med Microbiol. 304(1):1-2.

Schreiber, F., C. Szekat, M. Josten, H.-G. Sahl, G. Bierbaum. 2013. Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus. Antimicrob Agents Chemother. 57(12):6381-4.

Felder, S., S. Kehraus, E. Neu, G. Bierbaum, T.F. Schäberle, G.M. König. 2013. Salimyxins and enhygrolides: antibiotic, sponge-related metabolites from the obligate marine myxobacterium Enhygromyxa salina. Chembiochem. 14(11):1363-71. 

Felder, S., S. Dreisigacker, S. Kehraus, E. Neu, G. Bierbaum, P.R. Wright, D. Menche, T.F. Schäberle, G. M. König. 2013. Salimabromide: unexpected chemistry from the obligate marine myxobacterium Enhygromxya salina. Chemistry. 2013 19(28):9319-24.

Josten, M., M. Reif, C. Szekat, N. Al-Sabti, T. Roemer, K. Sparbier, M. Kostrzewa, H. Rohde, H.-G. Sahl, G. Bierbaum. 2013. Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages. J Clin Microbiol. 51(6):1809-17.

Jansen, A., C. Szekat, W. Schröder, C. Wolz, C. Goerke, J.C. Lee, M. Türck, G. Bierbaum. 2013. Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility. BMC Microbiol. 13:65.

Arnison P.G, Bibb M.J, Bierbaum G., Bowers A.A., Bugni T.S., Bulaj G., Camarero J.A., Campopiano D.J., Challis G.L., Clardy J., Cotter P.D., Craik D.J., Dawson M., Dittmann E., Donadio S., Dorrestein P.C., Entian K.D., Fischbach M.A., Garavelli J.S., Göransson U., Gruber C.W., Haft D.H., Hemscheidt T.K., Hertweck C., Hill C., Horswill AR., Jaspars M., Kelly W.L., Klinman J.P., Kuipers O.P., Link A.J., Liu W., Marahiel M.A., Mitchell D.A., Moll G.N., Moore B.S., Müller R., Nair S.K., Nes I.F., Norris G.E., Olivera B.M., Onaka H., Patchett M.L., Piel J., Reaney M.J., Rebuffat S., Ross R.P., Sahl H.G., Schmidt E.W., Selsted M.E., Severinov K., Shen B., Sivonen K., Smith L., Stein T., Süssmuth R.D., Tagg J.R., Tang G.L., Truman A.W., Vederas J.C., Walsh C.T., Walton J.D., Wenzel S.C., Willey J.M., van der Donk W.A. 2013. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 30(1):108-60.

Schulte B., Bierbaum G., Pohl K., Goerke C., Wolz C. 2013. Diversification of clonal complex 5 methicillin-resistant Staphylococcus aureus strains (Rhine-Hesse clone) within Germany. J Clin Microbiol. 51(1):212-6.

Sass, P., A. Berscheid, A. Jansen, M. Oedenkoven, C. Szekat, A. Strittmatter, G. Gottschalk, and G. Bierbaum. 2012. Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics. J Bacteriol. 194(8):2107-8.

Berscheid, A., P. Sass, K. Weber-Lassalle, A.L. Cheung, and G. Bierbaum. 2012. Revisiting the genomes of the Staphylococcus aureus strains NCTC 8325 and RN4220. Int J Med Microbiol. 302(2):84-7.

Türck, M. and G. Bierbaum. 2012. Purification and activity testing of the full-length YycFGHI proteins of Staphylococcus aureus. PLoS One. 7(1):e30403.

Herzner, A. M., J. Dischinger, C. Szekat, M. Josten, S. Schmitz, A. Yakeleba, R. Reinartz, A. Jansen, H. G. Sahl, J. Piel, and G. Bierbaum. 2011. Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42. PLoS One. 6:e22389.

Heinrich, N., A. Mueller, P. Bartmann, A. Simon, G. Bierbaum, and S. Engelhart. 2011. Successful management of an MRSA outbreak in a neonatal intensive care unit. Eur J Clin Microbiol Infect Dis. 30:909-913.

Nagel, M., T. Reuter, A. Jansen, C. Szekat, and G. Bierbaum. 2011. Influence of ciprofloxacin and vancomycin on mutation rate and transposition of IS256 in Staphylococcus aureus. Int J Med Microbiol. 301:229-236.

Schäberle, T. F., E. Goralski, E. Neu, O. Erol, G. Holzl, P. Dormann, G. Bierbaum, and G. M. König. 2010. Marine myxobacteria as a source of antibiotics--comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina. Mar Drugs. 8:2466-2479. 

 

 

2005 - 2009

 

Dischinger, J., M. Josten, C. Szekat, H.-G. Sahl, G. Bierbaum. 2009. Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One. 4(8):e6788.

Marklein, G., M. Josten, U. Klanke, E. Müller, R. Horré, T. Maier, T. Wenzel, M. Kostrzewa, G. Bierbaum, A. Hoerauf, H.-G. Sahl. 2009. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for fast and reliable identification of clinical yeast isolates. J Clin Microbiol. 47(9):2912-7.

Appleyard, A.N., Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BA, Dawson MJ, Cortes J. 2009. Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol. 16(5):490-8.

Bierbaum G, Sahl HG. 2009. Lantibiotics: mode of action, biosynthesis and bioengineering. Curr Pharm Biotechnol. 10(1):2-18.

Sass, P., G. Bierbaum. 2009. Native graS mutation supports the susceptibility of Staphylococcus aureus strain SG511 to antimicrobial peptides. Int J Med Microbiol. 299(5):313-22.

Sass, P., A. Jansen, C. Szekat, V. Sass, H.-G. Sahl, G. Bierbaum. 2008. The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus. BMC Microbiol. 8(1):186.

Sass, V., U. Pag, A. Tossi, G. Bierbaum, H.-G. Sahl. 2008. Mode of action of human β-defensin 3 (hBD3) against Staphylococcus aureus and transcriptional analysis of responses to defensin challenge. Int J Med Microbiol. 298: 619-633.

Bagci, S., A.M. Eis-Hübinger, A.R. Franz, G. Bierbaum, A. Heep, O. Schildgen, P. Bartmann, B. Kupfer, A. Mueller. 2008. Detection of astrovirus in premature infants with necrotizing enterocolitis. Pediatr Infect Dis J. 27(4):347-50.

Bonness, S., C. Szekat, N. Novak, G. Bierbaum. 2008. Pulsed field gel electrophoresis of Staphylococcus aureus isolates from atopic patients reveals presence of similar strains on the children and their parents. J Clin Microbiol. 46: 456-461.

Hübscher, J., A. Jansen, O. Kotte, J. Schäfer, P. A. Majcherczyk, L. G. Harris, G. Bierbaum, M. Heinemann, B. Berger-Bächi. 2007. Living with an imperfect cell wall: Compensation of femAB inactivation in Staphylococcus aureus. BMC Genomics. 8:307.

Bierbaum, G., A. Jansen. 2007. Tying the knot: making of lasso peptides. Chem Biol. 14:734-735.

Simon, A., G. Bierbaum, S. Engelhart, M. Exner, M. Kramer, U. Bode, G. Fleischhack and the study group Onkopaed 2001. 2007. Nosocomial Clostridium difficile-associated  disease in pediatric cancer patients - results from prospective German surveillance study. Hygiene und Medizin 32:177-18.

Becker, K., G. Bierbaum, C. von Eiff, S. Engelmann, F. Götz, J. Hacker, M. Hecker, G. Peters, R. Rosenstein, W. Ziebuhr. 2007. Understanding the physiology and adaptation of staphylococci: A post-genomic approach. Int J Med Microbiol. 297: 483-501.

Jansen, A., M. Türck, C. Szekat, M. Nagel, I. Clever, G. Bierbaum. 2007. Role of insertion elements and yycFG in the development of decreased susceptibility to vancomycin in Staphylococcus aureus. Int J Med Microbiol. 297:205-215

Rayani, A., U. Bode, E. Habas, G. Fleischhack, S. Engelhart, M. Exner, O. Schildgen, G. Bierbaum, A.-M. Eis-Hübinger, A. Smith. 2007. Rotavirus infections in paediatric oncology patients: A matched-pairs analysis. Scand J Gastroenterol. 42:81-87.

Sass, P., G. Bierbaum. 2007. Lytic activity of recombinant phage {phi}11 and {phi}12 endolysins on whole cells and biofilms of Staphylococcus aureus. Appl Environ Microbiol. 73:347-352.

Schmitz, S., A. Hoffmann, C. Szekat, B. Rudd, G. Bierbaum. 2006. The lantibiotic mersacidin is an autoinducing peptide. Appl Environ Microbiol. 72:7270-7277.



2000 - 2005

 

Kruszewska, D., H.-G. Sahl, G. Bierbaum, U. Pag, S.O. Hynes, Å. Ljungh. 2004. Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model. J Antimicrob Chemother. 54:648-653.

Schaaff, F., G. Bierbaum, N. Baumert, P. Bartmann, H.-G. Sahl. 2003. Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus. Int J Med Microbiol. 293:427-435.

Szekat C., R.W. Jack, D. Skutlarek, H. Färber, G. Bierbaum. 2003. Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin. Appl Environ Microbiol. 69:3777-3783.

Hsu S.T., E. Breukink, G. Bierbaum, H.-G. Sahl, B. de Kruijff, R. Kaptein, N.A. van Nuland, A.M. Bonvin. 2003. NMR study of mersacidin and lipid II interaction in DPC micelles: Conformational changes are a key to antimicrobial activity. J Biol Chem. 278:13110-13117.

Reipert A., K. Ehlert, T. Kast, G. Bierbaum. 2003. Morphological and genetic differences in two isogenic Staphylococcus aureus strains with decreased susceptibilities to vancomycin. Antimicrob Agents Chemother. 47:568-576.

Schaaff, F., A. Reipert, G. Bierbaum. 2002. An elevated mutation frequency favors development of vancomycin resistence in Staphylococcus aureus. Antimicrob Agents Chemother. 46:3540-3548.

Majer, F., D.G. Schmid, K. Altena, G. Bierbaum, T. Kupke. 2002. The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin. J Bacteriol. 184:1234-1243.

Guder, A., T. Schmitter, I. Wiedemann, H.-G. Sahl, G. Bierbaum. 2002. Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity. Appl Environ Microbiol .68:106-113.

Lenz, W., N. Blümel, G. Bierbaum, B. Herding-Sotzek und P.M. Shah. 2001. Resistenzentwicklung bei S. aureus und Typenwechsel bei MRSA-Stämmen. Chemotherapie Journal. 5:176-182.

Lee, H.J., J.T. Suh, Y.S. Kim, W. Lenz, G. Bierbaum, K.P. Schaal. 2001. Typing and antimicrobial susceptibilities of methicillin resistant Staphylococcus aureus (MRSA) Strains Isolated in a Hospital in Korea. J. Korean Med. Sci.16:381-385.

Wiedemann, I., E. Breukink, C. van Kraaij C., O.P. Kuipers, G. Bierbaum, B. de Kruijff, H.-G. Sahl. 2001. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J Biol Chem. 276:1772-1779.

Altena, K., A. Guder, C. Cramer, G. Bierbaum. 2000. Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster. Appl Environ Microbiol. 66:2565-2571.

Beukes, M., G. Bierbaum, H.-G. Sahl, J.W. Hastings. 2000. Purification and partial characterization of a murein hydrolase, millericin B produced by Streptococcus milleri NMSCC 061. Appl Environ Microbiol. 66:23-28.

Dommke, A., W. Lenz, G. Bierbaum,  H. Werner. 2000. Typisierung von Staphylococcus-aureus-Isolaten bei intensivpflichtigen Patienten. Hyg Med. 25:129-134

 

1995 - 1999

 

Bierbaum, G., K. Fuchs, W. Lenz, C. Szekat, H.-G. Sahl. 1999. Presence of Staphylococcus aureus with reduced susceptibility to vancomycin in Germany. Eur J Clin Microbiol Infect. Dis. 18:691-696.

Pag, U., C. Heidrich, G. Bierbaum, H.-G. Sahl. 1999. Molecular analysis of expression of the lantibiotic Pep5 immunity phenotype. Appl Environ Microbiol. 65:591-598.

Sahl, H.-G., G. Bierbaum. 1998. Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria. Annu Rev Microbiol. 52:41-79.

Brötz, H., M. Josten, I. Wiedemann, U. Schneider, F. Götz, G. Bierbaum, H.-G. Sahl. 1998. Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics. Mol Microbiol. 30:317-327.

Heidrich, C., U. Pag, M. Josten, J. Metzger, R.W. Jack, G. Bierbaum, G. Jung, H.-G. Sahl. 1998. Isolation, characterization, and heterologous expression of the novel lantibiotic epicidin 280 and analysis of its biosynthetic gene cluster. Appl Environ Microbiol. 64:3140-3146.

Brötz, H., G. Bierbaum, K. Leopold, P.E. Reynolds, H.-G. Sahl. 1998. The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II. Antimicrob Agents Chemother. 42:154-160.

Brötz, H., G. Bierbaum, P.E. Reynolds, H.-G. Sahl. 1997. The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation. Eur J Biochem. 246:193-199.

Neis, S., G. Bierbaum, M. Josten, U. Pag, C. Kempter, G. Jung, H.-G. Sahl. 1997. Effect of leader peptide mutations on biosynthesis of the lantibiotic Pep5. FEMS Microbiol Lett. 149:249-255.

Molitor, E., C. Kluczny, H. Brötz, G. Bierbaum, R.W. Jack, H.-G. Sahl. 1996. Effects of the lantibiotic mersacidin on the morphology of staphylococci. Zentralbl Bakteriol. 284:318-328.

Heidrich, C., K. Hantke, G. Bierbaum, and H.-G. Sahl. 1996. Identification and analysis of a gene cluster encoding a Fur-like protein of Staphylococcus epidermidis. FEMS Microbiol Lett. 140:253-259.

Kuipers, O.P., G. Bierbaum, B. Ottenwälder, H.M. Dodd, N. Horn, J. Metzger, T. Kupke, V. Gnau, R. Bongers, P. van den Bogaard, H. Kosters, H.S. Rollema, W.M. de Vos, R.J. Siezen, G. Jung, F. Götz, H.-G. Sahl, M.J. Gasson. 1996. Protein engineering of lantibiotics. Antonie Van Leeuwenhoek 69:161-169.

Bierbaum, G., F. Götz, A. Peschel, T. Kupke, M. van de Kamp, H.-G. Sahl. 1996. The biosynthesis of the lantibiotics epidermin, gallidermin, Pep5, and epilancin K7. Antonie Van Leeuwenhoek 69:119-127.

Bierbaum, G., C. Szekat, M. Josten, C. Heidrich, C. Kempter, G. Jung, H.-G. Sahl. 1996. Engineering of a novel thioether bridge and role of modfied residues in the lantibiotic Pep5. Appl Environ Microbiol. 62:385-392.

Jack, R.W., G. Bierbaum, C. Heidrich, H.-G. Sahl. 1995. The genetics of lantibiotic biosynthesis. Bioassays 17:793-802.

Meyer, C., G. Bierbaum, C. Heidrich, M. Reis, J. Süling, M.I. Iglesias-Wind, C. Kempter, E. Molitor, H.-G. Sahl. 1995. Nucleotide sequence of the lantibiotic Pep5 biosynthesis gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation. Eur J Biochem. 232:478-489.

Sahl, H.-G., R.W. Jack, G. Bierbaum. 1995. Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem. 230:827-853.

van de Kamp, M., H.W. van den Hooven, R.N. Konings, G. Bierbaum, H.-G. Sahl, O.P. Kuipers, R.J. Siezen, W.M. de Vos, C.W. Hilbers, F.J. van de Ven. 1995. Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterization of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7. Eur J Biochem. 230:587-600. 

Bierbaum, G., H. Brötz, K.P. Koller, H.-G. Sahl. 1995. Cloning, sequencing and production of the lantibiotic mersacidin. FEMS Microbiol Lett. 127:121-126.

Brötz, H., G. Bierbaum, A. Markus, E. Molitor, H.-G. Sahl. 1995. Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism? Antimicrob Agents Chemther. 39:714-719.

 

1985 - 1994

 

Bierbaum, G., M. Reis, C. Szekat, H.-G. Sahl. 1994. Construction of an expression system for engineering of the lantibiotic Pep5. Appl Environ Microbiol. 60:4332-4328.

Bierbaum, G., M. Karutz, D. Weuster-Botz, C. Wandrey. 1994. Production of protease with Bacillus licheniformis mutants insensitive to repression of exoenzyme biosynthesis. Appl Microbiol Biotechnol. 40:611617.

Bierbaum, G., H.-G. Sahl. 1993. Lantibiotics - unusually modified bacteriocin-like peptides from gram-positive bacteria. Zentralbl Bakteriol. 278:1-22.

Giesecke, U.E., G. Bierbaum, H. Rudde, U. Spohn, C. Wandrey. 1991. Production of alkaline protease with Bacillus licheniformis in a controlled fed-batch process. Appl Microbiol Biotechnol. 35:720-724.

Bierbaum, G., U.E. Giesecke, C. Wandrey. 1991. Analysis of nucleotide pools during protease production with Bacillus licheniformis. Appl Microbiol Biotechnol. 35:725-730.

Bierbaum, G., H.-G. Sahl. 1989. Influence of cationic peptides on the activity of the autolytic endo-beta-N-acetylglucosaminidase of Staphylococcus simulans 22. FEMS Microbiol Lett. 49:223-227.

Sahl, H.-G., H. Ersfeld-Dreßen, G. Bierbaum, M. Josten, M. Kordel, M. Reis, F. Schüller. 1987. Different mechanisms of insensitivity to the staphylococcin-like peptide Pep5. Zentralbl Bakteriol Mikrobiol Hyg. [A] 267:173-185.

Bierbaum, G., H.-G. Sahl. 1987. Autolytic system of Staphylococcus simulans 22: influence of cationic peptides on activity of N-acetylmuramoyl-L-alanine amidase. J Bacteriol. 169:5452-5458.

Bierbaum, G., H.-G. Sahl. 1985. Induction of autolysis of staphylococci by the basic peptide antibiotics Pep5 and nisin and their influence on the activity of autolytic enzymes. Arch Microbiol. 141:249-254.

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Patents:

 

Giesecke, U.E., G. Bierbaum, C. Wandrey

Verfahren zur Gewinnung von alkalischer SerinProtease durch ammoniumlimitierte Fermentation von Bacillus-Stämmen. Deutsches Patent Nr. 39 21 764

Koller, HP,  Sahl HG, Bierbaum G.

US5667991/EP 0700998 A17 und DE 69433357 T2. Recombinant mersacidin and a method for production (1997). 

Dawson, M, Cortes-Bargallo J, Rudd BAM, Boakes S, Bierbaum G, Hoffman A, Schmitz S.

US 7592308 B2. F3W variants of the lantibiotic mersacidin and its use (2009).

 

 

Patent Application:

 

Bierbaum G, Szekat C, Alsabti N, Josten M, Reif M.

WO2015/097061 (A1). Identification of methicillin resistant Staphylococcus aureus (MRSA) (2015).

 

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Book Chapters:

 

Bierbaum, G., R. W. Jack, H.-G. Sahl: 560. Lantibiotic leader peptidases. In: Handbook of proteolytic enzymes (A. Barret, N. D. Rawlings, J. F. Woessner, Hsg.), 1st  (1998) and 2nd Edition, Elsevier Ltd., S. 1815-1817 (2004)

Jack, R. W., G. Bierbaum, H.-G. Sahl: 387. Translocator-associated peptidases. In: Handbook of proteolytic enzymes (A. Barret, N. D. Rawlings, J. F. Woessner, Hsg.), 1st (1998) and 2nd Edition, Elsevier Ltd., S. 1253-1257 (2004)

Bartmann, P., G. Bierbaum , H.-G. Sahl, W. Witte: Staphylokokkeninfektionen. In: Handbuch Infektionen bei Kindern und Jugendlichen, 4. Auflage (Deutsche Gesellschaft für pädiatrische Infektiologie e.V., Hsg.), Futuramed Verlag, München 640-644 (2003)

Bierbaum, G.: Mersacidin – ein neues (L)antibiotikum. Bioforum 26, 464-465 (2003)

Bierbaum, G.: 17. Genetics of lantibiotic biosynthesis. In: Comprehensive Natural Products Chemistry, Bd.4 (D. Barton, K. Nakanishi, O. Meth-Cohn, J. W. Kelly, Hsg.), Elsevier Science, Oxford, S. 275-304 (1999)

Bierbaum, G.: Antibiotische Peptide - Lantibiotika. Chemotherapie Journal 8, 204-209 (1999)

Bierbaum, G. 1999. Genetics of lantibiotic biosynthesis. p. 275-254. In: J.W. Kelly (ed.), volume 4, Amino acids, peptides, prophyrins, and alkaloids. Amsterdam: Elsevier.

Bierbaum, G., H. Brötz, H.-G. Sahl. 1997. Lanthionine-containing antibiotic peptides (lantibiotics): Features, functions and prespectives. Biospektrum 2:51-55.

Bierbaum, G., H. Brötz, H.-G. Sahl. 1996. Modes of action of lantibiotics, p. 125-134. In: S.G. Pandalai (ed.), Recent Research Developments in Antimicrobial Agents and Chemotherapy. Trivandrum: Research Signpost.

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Book:

 

Jack, R.W., G. Bierbaum, H.-G. Sahl. 1998. Lantibiotics and related peptides. Springer Verlag, Berlin, Heidelberg, New York. ISBN: 3-540-63600-5

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